PROVIDES EXTENSIVE OPPORTUNITIES FOR THE DISCOVERY OF NOVEL

INSIGHTS THROUGH MINING AND REANALYSIS. FROM ATLASES TO

SIMULATIONS, BIOLOGICAL LANGUAGE MODELS AND SYNTHETIC

DATASETS, WE EXPLORE HOW MULTIOMICS DATA IS INFORMING THE

DIGITAL ERA, AND HOW WE ALL HAVE A ROLE TO PLAY IN GENERATING

DATA THAT WILL BE USEFUL BEYOND ITS INITIAL PURPOSE.

MEDICINE. FROM BOLSTERING DRUG DISCOVERY AND

DEVELOPMENT, TO IMPROVING PATIENT DIAGNOSIS AND

STRATIFICATION, MULTIMODAL TESTING IS PAVING THE WAY

FOR PERSONALISED MEDICINE AND HOLISTIC HEALTHCARE. THIS

CHAPTER INVESTIGATES SEVERAL CASE STUDIES THAT EXEMPLIFY

THE USE OF MULTIOMICS IN PRECISION MEDICINE, SUCH AS THE

DEVELOPMENT OF PERSONALISED VACCINES AND THE USE OF

ELECTRONIC HEALTH RECORDS IN MULTIMODAL PLATFORMS.

THE INTEGRATION OF DATA. A WEALTH OF COMMERCIAL AND OPEN-

SOURCE SOLUTIONS EXISTS, WITH MANY OFFERING MACHINE LEARNING

CAPABILITIES TO DRAW INSIGHTS FROM SEEMINGLY DISPARATE DATA.

HERE, YOU WILL DISCOVER NOVEL PUBLICATIONS DISCUSSING THE KEY

CHALLENGES FACING DATA INTEGRATION, ALONGSIDE INTERVIEWS AND

INSIGHTS FROM THE AUTHORS GIVING CLARITY AND EXPERT ADVICE.

TOPICS INCLUDE DATA HETEROGENEITY, THE CURSE OF DIMENSIONALITY

AND SOLUTIONS FOR THOSE WITHOUT BIOINFORMATICS EXPERTISE.

THE CENTRAL DOGMA. MULTIMODAL TECHNIQUES ARE BEING

USED TO MAP THE SECRETOME, INTERACTOME AND HOLOGENOME,

AMONGST OTHERS. THIS CHAPTER EXPLORES THE POSSIBILITIES

OF MULTIOMICS RESEARCH AT A SYSTEMS BIOLOGY LEVEL, FROM

HOW ENDOPHENOTYPE RESEARCH IS BRIDGING SCALES BETWEEN

MOLECULES AND PHENOTYPES, TO HOW MULTIMODAL ANALYSIS OF

THE EXPOSOME CAN SHED LIGHT ON THE BIOLOGICAL IMPACT OF AN

INDIVIDUAL’S ENVIRONMENT.

INVESTIGATING TISSUE, ALLOWING THE INTERROGATION OF MULTIPLE

MODALITIES THAT ARE COMPLEMENTED BY MORPHOLOGICAL AND

SPATIAL CONTEXT. THIS CHAPTER DISCUSSES THE TYPES OF SINGLE

OMES THAT CAN BE COMBINED IN SPATIAL STUDIES, CONSIDERING BOTH

COMMERCIAL AND OPEN-SOURCE APPLICATIONS. DIGITAL PATHOLOGY

IS HIGHLY COMPATIBLE WITH SPATIAL MULTIOMICS; HISTOLOGY IS

ROUTINELY PERFORMED, AND WE EXPLORE HOW THIS MORPHOLOGICAL

INFORMATION CAN BOLSTER SPATIAL STUDIES AND INSIGHTS.

EACH LAYER OFFERING UNIQUE INSIGHTS. BRINGING THESE MODALITIES

TOGETHER BUILDS A CLEARER PICTURE OF CELLULAR BIOLOGY, WHILE

GENERATING A WEALTH OF DATA FOR FUTURE INVESTIGATION. HERE, WE

EXPLORE A SELECTION OF COMMERCIAL AND OPEN-SOURCE PLATFORMS

THAT COMBINE PROTEIN AND NUCLEIC ACID DETECTION, DETAILING

THEIR BENEFITS AND LIMITATIONS, WHILE PROVIDING RECENT USE

CASES. THE CRUCIAL ROLE OF THE WET LABORATORY SCIENTIST IS ALSO

DISCUSSED AS WE MOVE INTO THIS DIGITAL ERA.