Learning from Machine Learning

Dan Bricklin: Lessons from Building the First Killer App | Learning from Machine Learning #14

Fri, 17 Oct 2025 10:00:31 GMT

On this episode of Learning from Machine Learning, I had the pleasure of speaking with Dan Bricklin, co-creator of VisiCalc - the first electronic spreadsheet and the killer app that launched the personal computer revolution. We explored what five decades of platform shifts teach us about today's AI moment.

Dan's framework is simple but powerful: breakthrough innovations must be 100 times better, not incrementally better. The same questions he asked about spreadsheets apply to AI today: What is this genuinely better at? What does it enable? What trade-offs will people accept? Does it pay for itself immediately?

Most importantly, Dan reminded us that we never fully know the impact of what we build. Whether it's a mother whose daughter with cerebral palsy can finally do her own homework, or a couple who met learning spreadsheets. The moments worth remembering aren't the product launches or exits. They're the unexpected times when your work changes someone's life in ways you never imagined.

Substack

Youtube

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Chapters

00:00:00 Start

00:00:49 Early Fascination with Technology

00:02:49 From MIT to Mainframes: A Journey Through Computing

00:09:35 The Birth of VisiCalc: Revolutionizing Spreadsheets

00:13:41 Interactive Computing: The Impact of VisiCalc

00:16:46 Understanding Killer Apps: The Evolution of Software

00:23:05 Challenges in Development: Creating VisiCalc

00:30:12 VisiCalc's Legacy: The Precursor to Modern Spreadsheets

00:36:01 App Customization

00:40:31 The Evolution of User Interfaces and Applications

00:43:11 Understanding AI: Hype vs. Reality

00:48:11 Learning to Use New Technologies Effectively

00:56:51 The Importance of User-Centric Design

01:01:10 Career Reflections and Life Lessons

01:05:18 The Impact of Technology on Life and Relationships

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A machine learning podcast that explores more than just algorithms and data: Life lessons from the experts. Welcome to "Learning from Machine Learning," a podcast about the insights gained from a career in the field of Machine Learning and Data Science. In each episode, industry experts, entrepreneurs and practitioners will share their experiences and advice on what it takes to succeed in this rapidly-evolving field.

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Resources to learn more about Learning from Machine Learning

Lukas Biewald | You think you're late, but you're early | Learning from Machine Learning #13

Tue, 01 Jul 2025 10:20:19 GMT

On this episode of Learning from Machine Learning, I had the privilege of speaking with Lukas Biewald, co-founder and CEO of Weights & Biases. We traced his journey from programming games as a kid to building one of the most essential tools in AI development today. Lukas's career demonstrates that conviction often matters more than consensus—from surviving the AI winter in the mid-2000s when he was coached to remove "AI" from investor pitches, to the AlphaGo moment that changed everything and led him to take an unpaid internship at OpenAI in his thirties.

Lukas's philosophy on "automating the automation" reveals why AI developers have become the most powerful people within organizations—they're a smaller market but wield disproportionate influence. He shares his view that "if you zoom out, AI is so underhyped, you can't hype it enough." The recursive potential of machines improving machines is barely understood, yet it represents "the most powerful technology you could possibly build."

Most importantly, Lukas's philosophy that "feedback loops are your units of work" transforms how we approach both machine learning and life. He explains the necessity to stay technical as a leader: "If you're going to work for me, you better be able to do the IC job. And I do not know how companies function without that mindset." His advice to his younger self cuts through common doubts in emerging technologies: "you think you're late, but you're early." In a world racing towards progress at all costs, this reminder couldn't be more relevant.

Thank you for listening. Be sure to subscribe and share with a friend or colleague.

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Available on all podcast platforms:

https://rss.com/podcasts/learning-from-machine-learning/

Available on Youtube:

https://www.youtube.com/@learningfrommachinelearning

Available on Substack:

https://mindfulmachines.substack.com/

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Chapters

00:00 Open

00:46 Early Fascination with AI

03:57 Founding CrowdFlower During AI Winter

09:22 The AlphaGo Awakening

16:02 Birth of Weights & Biases

23:50 The LLM Revolution's Impact

29:12 CoreWeave Acquisition & Future Vision

32:56 The Entrepreneurship Philosophy

37:29 Technical Leadership Philosophy

49:01 The Future of Software Development

53:07 Leadership Lessons & Career Advice

1:00:38 Life Lessons from Machine Learning

1:01:46 Closing Thoughts & Gratitude

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References

Gödel, Escher, Bach: An Eternal Golden Braid
Genius Makers
Weights & Biases
CrowdFlower/Figure 8 (now part of Appen)
OpenAI
CoreWeave
Scale AI
GitHub
Google
Stanford University
Y Combinator
Daphne Koller - Stanford Professor, Co-founder of Coursera
Lee Sedol - Professional Go player defeated by AlphaGo

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Maxime Labonne: Designing beyond Transformers | Learning from Machine Learning #12

Wed, 28 May 2025 23:04:48 GMT

On this episode of Learning from Machine Learning, I had the privilege of speaking with Maxime Labonne, Head of Post-Training at Liquid AI. We traced his journey from cybersecurity to the cutting edge of model architecture. Maxime shared how the future of AI isn't just about making models bigger—it's about making them smarter and more efficient.

Maxime's work demonstrates that challenging established paradigms requires taking steps backward to leap forward. His framework for data quality—accuracy, diversity, and complexity—offers a blueprint for anyone working with machine learning systems.

Most importantly, Maxime's perspective on learning itself—treating knowledge acquisition like training data exposure—reminds us that growth comes from diverse, high-quality experiences across different contexts. Whether you're training a model or developing yourself, the principles remain remarkably similar.

Thank you for listening. Be sure to subscribe and share with a friend or colleague. Until next time... keep on learning.

00:46 Introduction and Maxime's Background

01:47 Journey from Cybersecurity to Machine Learning

03:30 The Fascination with AI and Cyber Attacks

06:15 Transitioning to Post-Training at Liquid AI

08:17 Liquid AI's Vision and Mission

10:08 Challenges of Deploying AI on Edge Devices

13:06 Techniques for Efficient Edge Model Training

15:44 The State of AI Hype and Reality

19:19 Evaluating AI Models and Benchmarks

24:09 Future of AI Architectures Beyond Transformers

31:05 Innovations in Model Architecture

36:28 The Importance of Iteration in AI Development

39:24 Understanding State Space Models

42:53 Advice for Aspiring Machine Learning Professionals

48:53 The Quest for Quality Data

52:56 Integrating User Feedback into AI Systems

58:13 Lessons from Machine Learning for Life

Aman Khan: Arize, Evaluating AI, Designing for Non-Determinism | Learning from Machine Learning #11

Tue, 29 Apr 2025 18:39:24 GMT

On this episode of Learning from Machine Learning, I had the privilege of speaking with Aman Khan, Head of Product at Arize AI. Aman shared how evaluating AI systems isn't just a step in the process—it's a machine learning challenge in of itself. Drawing powerful analogies between mechanical engineering and AI, he explained, "Instead of tolerances in manufacturing, you're designing for non-determinism," reminding us that complexity often breeds opportunity.

Aman's journey from self-driving cars to ML evaluation tools highlights the critical importance of robust systems that can handle failure. He encourages teams to clearly define outcomes, break down complex systems, and build evaluations into every step of the development pipeline.

Most importantly, Aman's insights remind us that machine learning—much like life—is less deterministic and more probabilistic, encouraging us to question how we deal with the uncertainty in our own lives.

Thank you for listening. Be sure to subscribe and share with a friend or colleague . Until next time... keep on learning.

Available on Youtube: https://youtu.be/v0eTTn7ZPEc

Available on Substack: https://mindfulmachines.substack.com/p/aman-khan-arize-evaluating-ai-designing?r=eykwy

Leland McInnes: UMAP, HDBSCAN & the Geometry of Data | Learning from Machine Learning #10

Fri, 25 Oct 2024 13:36:12 GMT

In this episode of Learning from Machine Learning, we explore the intersection of pure mathematics and modern data science with Leland McInnes, the mind behind an ecosystem of tools for unsupervised learning including UMAP, HDBSCAN, PyNN Descent and DataMapPlot. As a researcher at the Tutte Institute for Mathematics and Computing, Leland has fundamentally shaped how we approach and understand complex data.

Leland views data through a unique geometric lens, drawing from his background in algebraic topology to uncover hidden patterns and relationships within complex datasets. This perspective led to the creation of UMAP, a breakthrough in dimensionality reduction that preserves both local and global data structure to allow for incredible visualizations and clustering. Similarly, his clustering algorithm HDBSCAN tackles the messy reality of real-world data, handling varying densities and noise with remarkable effectiveness.

But perhaps what's most striking about Leland isn't just his technical achievements – it's his philosophy toward algorithm development. He champions the concept of "decomposing black box algorithms," advocating for transparency and understanding over blind implementation. By breaking down complex algorithms into their fundamental components, Leland argues, we gain the power to adapt and innovate rather than simply consume.

For those entering the field, Leland offers poignant advice: resist the urge to chase the hype. Instead, find your unique angle, even if it seems unconventional. His own journey – applying concepts from algebraic topology and fuzzy simplicial sets to data science – demonstrates how breakthrough innovations often emerge from unexpected connections.

Throughout our conversation, Leland's passion for knowledge and commitment to understanding shine through. His approach reminds us that the most powerful advances in data science often come not from following the crowd, but from diving deep into fundamentals and drawing connections across disciplines.

There's immense value in understanding the tools you use, questioning established approaches, and bringing your unique perspective to the field. As Leland shows us, sometimes the most significant breakthroughs come from seeing familiar problems through a new lens.

Resources for Leland McInnes

Leland’s Github

UMAP
HDBSCAN
PyNN Descent
DataMapPlot
EVoC

References

Maarten Grootendorst
- Learning from Machine Learning Episode 1
Vincent Warmerdam - Calmcode
- Learning from Machine Learning Episode 2
Matt Rocklin
Emily Riehl - Category Theory in Context
Lorena Barba
David Spivak - Fuzzy Simplicial Sets
Improving Mapper’s Robustness by Varying Resolution According to Lens-Space Density

Learning from Machine Learning

Chris Van Pelt: Machine Learning Tooling, Weights and Biases, Entrepreneurship | Learning from Machine Learning #9

Fri, 01 Mar 2024 17:34:54 GMT

In this episode, we are joined by Chris Van Pelt, co-founder of Weights & Biases and Figure Eight/CrowdFlower. Chris has played a pivotal role in the development of MLOps platforms and has dedicated the last two decades to refining ML workflows and making machine learning more accessible.

Throughout the conversation, Chris provides valuable insights into the current state of the industry. He emphasizes the significance of Weights & Biases as a powerful developer tool, empowering ML engineers to navigate through the complexities of experimentation, data visualization, and model improvement. His candid reflections on the challenges in evaluating ML models and addressing the gap between AI hype and reality offer a profound understanding of the field's intricacies.

Drawing from his entrepreneurial experience co-founding two machine learning companies, Chris leaves us with lessons in resilience, innovation, and a deep appreciation for the human dimension within the tech landscape. As a Weights & Biases user for five years, witnessing both the tool and the company's growth, it was a genuine honor to host Chris on the show.

References and Resources

https://wandb.ai/

https://www.youtube.com/c/WeightsBiases

https://x.com/weights_biases

https://www.linkedin.com/company/wandb/

https://twitter.com/vanpelt

Resources to learn more about Learning from Machine Learning

Michelle Gill: AI-Assisted Drug Discovery, NVIDIA, Biofoundation Models, Creating Applied Research Teams | Learning from Machine Learning #8

Thu, 11 Jan 2024 03:50:10 GMT

This episode features Dr. Michelle Gill, Tech Lead and Applied Research Manager at NVIDIA, working on transformative projects like BioNemo to accelerate drug discovery through AI. Her team explores Biofoundation models to enable researchers to better perform tasks like protein folding and small molecule binding.

Michelle shares her incredible journey from wet lab biochemist to driving cutting edge AI at NVIDIA. Michelle discusses the overlap and differences between NLP and AI in biology. She outlines the critical need for better machine learning representations that capture the intricate dynamics of biology.

Michelle provides advice for beginners and early career professionals in the field of machine learning, emphasizing the importance of continuous learning and staying up to date with the latest tools and techniques. She also shares insights on building successful multidisciplinary teams

After hearing her fascinating PyData NYC keynote, it was such an honor to have her on the show to discuss innovations at the intersection of biochemistry and AI.

References and Resources

https://michellelynngill.com/

Michelle Gill - Keynote - PyData NYC https://www.youtube.com/watch?v=ATo2SzA1Pp4

AlexNet

AlphaFold - https://www.nature.com/articles/s41586-021-03819-2

OpenFold - https://www.biorxiv.org/content/10.1101/2022.11.20.517210v1

BioNemo - https://www.nvidia.com/en-us/clara/bionemo/

NeurIPS - https://nips.cc/

Art Palmer - https://www.biochem.cuimc.columbia.edu/profile/arthur-g-palmer-iii-phd

Patrick Loria - https://chem.yale.edu/faculty/j-patrick-loria

Scott Strobel - https://chem.yale.edu/faculty/scott-strobel

Alexander Rives - https://www.forbes.com/sites/kenrickcai/2023/08/25/evolutionaryscale-ai-biotech-startup-meta-researchers-funding/?sh=648f1a1140cf

Deborah Marks - https://sysbio.med.harvard.edu/debora-marks

Resources to learn more about Learning from Machine Learning

Ines Montani: Explosion, NLP, Generative AI, Entrepreneurship | Learning from Machine Learning #7

Thu, 26 Oct 2023 18:04:14 GMT

This episode features co-founder and CEO of Explosion, Ines Montani. Listen in as we discuss the evolution of the web and machine learning, the development of SpaCy, Natural Language Processing vs. Natural Language Understanding, the misconceptions of starting a software company, and so much more! Ines is a software developer working on Artificial Intelligence and Natural Language Processing technologies.

She's the co-founder and CEO of Explosion, the company behind SpaCy, one of the leading open-source libraries for NLP in Python and Prodigy, an annotation tool to help create training data for Machine Learning Models. Ines has an academic background in Communication Science, Media Studies and Linguistics and has been coding and designing websites since she was 11. She's been the keynote speaker at Python and Data Science conferences around the world.

Learning from Machine Learning, a podcast that explores more than just algorithms and data: Life lessons from the experts.

Listen on YouTube: https://youtu.be/XNFqFT-DZwo?si=Aj75TmsCyBQTyWqq

Listen on your favorite podcast platform:

https://rss.com/podcasts/learning-from-machine-learning/1190862/

References in the Episode

Resources to learn more about Learning from Machine Learning

Lewis Tunstall: Hugging Face, SetFit and Reinforcement Learning | Learning from Machine Learning #6

Tue, 03 Oct 2023 12:32:14 GMT

This episode features Lewis Tunstall, machine learning engineer at Hugging Face and author of the best selling book Natural Language Processing with Transformers. He currently focuses on one of the hottest topic in NLP right now reinforcement learning from human feedback (RLHF). Lewis holds a PhD in quantum physics and his research has taken him around the world and into some of the most impactful projects including the Large Hadron Collider, the world's largest and most powerful particle accelerator. Lewis shares his unique story from Quantum Physicist to Data Scientist to Machine Learning Engineer.

Resources to learn more about Lewis Tunstall

References from the Episode

https://www.fast.ai/
https://jeremy.fast.ai/
SetFit - https://arxiv.org/abs/2209.11055
Proximal Policy Optimization
InstructGPT
RAFT Benchmark
Bidirectional Language Models are Also Few-Shot Learners
Nils Reimers - Sentence Transformers
Jay Alammar - Illustrated Transformer
Annotated Transformer
Moshe Wasserblat, Intel, NLP, Research Manager
Leandro von Werra, Co-Author of NLP with Transformers, Hugging Face Researcher
LLMSys - https://lmsys.org/
LoRA - Low-Rank Adaptation of Large Language Models

Resources to learn more about Learning from Machine Learning

Paige Bailey: Google Deepmind, LLMs, Power of ML to improve code | Learning from Machine Learning #5

Fri, 19 May 2023 17:58:36 GMT

The episode features Paige Bailey, the lead product manager for generative models at Google DeepMind. Paige's work has helped transform the way that people work and design software using the power of machine learning. Her current work is pushing the boundaries of innovation with Bard and the soon to be released Gemini.

Resources to learn more about Paige Bailey
- https://twitter.com/DynamicWebPaige
- https://github.com/dynamicwebpaige
References from the Episode
- Diamond Age - Neal Stephenson - https://amzn.to/3BCwk4n
- Google Deepmind - https://www.deepmind.com/
- Google Research - https://research.google/
- Jax - https://jax.readthedocs.io/en/latest/
- Jeff Dean - https://research.google/people/jeff/
- Oriol Vinyals - https://research.google/people/OriolVinyals/
- Roy Frostig - https://cs.stanford.edu/~rfrostig/
- Matt Johnson - https://www.linkedin.com/in/matthewjamesjohnson/
- Peter Hawkins - https://github.com/hawkinsp
- Skye Wanderman-Milne - https://www.linkedin.com/in/skye-wanderman-milne-73887b29/
- Yash Katariya - https://www.linkedin.com/in/yashkatariya/
- Andrej Karpathy - https://karpathy.ai/
Resources to learn more about Learning from Machine Learning

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Learning from Machine Learning, a podcast that explores more than just algorithms and data: Life lessons from the experts.

Sebastian Raschka: Learning ML, Responsible AI, AGI | Learning from Machine Learning #4

Sun, 26 Mar 2023 18:02:06 GMT

This episode we welcome Sebastian Raschka, Lead AI Educator at Lightning and author of Machine Learning with Pytorch and Scikit-Learn to discuss the best ways to learn machine learning, his open source work, how to use chatGPT, AGI, responsible AI and so much more. Sebastian is a fountain of knowledge and it was a pleasure to get his insights on this fast moving industry. Learning from Machine Learning, a podcast that explores more than just algorithms and data: Life lessons from the experts. Resources to learn more about Sebastian Raschka and his work:

https://sebastianraschka.com/

https://lightning.ai/

Machine Learning with Pytorch and Scikit-Learn

Machine Learning Q and AI

Resources to learn more about Learning from Machine Learning and the host: https://www.linkedin.com/company/learning-from-machine-learning

https://www.linkedin.com/in/sethplevine/

https://medium.com/@levine.seth.p

twitter

References from Episode

https://scikit-learn.org/stable/

http://rasbt.github.io/mlxtend/

https://github.com/BioPandas/biopandas

Understanding and Coding the Self-Attention Mechanism of Large Language Models From Scratch

Andrew Ng - https://www.andrewng.org/

Andrej Karpathy - https://karpathy.ai/

Paige Bailey - https://github.com/dynamicwebpaige

Contents

01:15 - Career Background

05:18 - Industry vs. Academia

08:18 - First Project in ML

15:04 - Open Source Projects Involvement

20:00 - Machine Learning: Q&AI

24:18 - ChatGPT as Brainstorm Assistant

25:38 - Hype vs. Reality

27:55 - AGI

31:00 - Use Cases for Generative Models

34:01 - Should the goal to be to replicate human intelligence?

39:18 - Delegating Tasks using LLM

42:26 - ML Models are overconfident on Out of Distribution

44:54 - Responsible AI and ML

45:59 - Complexity of ML Systems

47:26 - Trend for ML Practitioners to move to AI Ethics

49:27 - What advice would you give to someone just starting out?

52:20 - Advice that you’ve received that has helped you

54:08 - Andrew Ng Advice

55:20 - Exercise of Implementing Algorithms from Scratch

59:00 - Who else has influenced you?

01:01:18 - Production and Real-World Applications - Don’t reinvent the wheel

01:03:00 - What has a career in ML taught you about life?

Nils Reimers: Sentence Transformers, Search, Future of NLP | Learning from Machine Learning #3

Fri, 24 Feb 2023 21:32:54 GMT

This episode welcomes Nils Reimers, Director of Machine Learning at Cohere and former research at Hugging Face, to discuss Natural Language Processing, Sentence Transformers and the future of Machine Learning. Nils is best known as the creator of Sentence Transformers, a powerful framework for generating high-quality sentence embeddings that has become increasingly popular in the ML community with over 9K stars on Github. With Sentence Transformers, Nils has enabled researchers and developers (including me) to train state-of-the-art models for a wide range of NLP tasks, including text classification, semantic similarity, and question-answering. His contributions have been recognized by numerous awards and publications in top-tier conferences and journals.

Resources to learn more about Nils Reimers and his work:

https://www.nils-reimers.de/

https://www.sbert.net/

https://scholar.google.com/citations ?...

https://cohere.ai/

Resources to learn more about Learning from Machine Learning:

https://www.linkedin.com/company/learning-from-machine-learning

https://www.linkedin.com/in/sethplevine/

https://medium.com/@levine.seth.p

Youtube Clips

02:29 What attracted you to Machine Learning?

06:32 What is sentence transformers?

28:02 Benchmarks and P-Hacking

33:53 What’s an important question that remains unanswered in Machine Learning?

38:41 How do you view the gap between the hype and the reality in Machine Learning?

50:45 What advice would you give to someone just starting out?

52:30 What advice would you give yourself when you were just starting out in your career?

57:22 What has a career in ML taught you about life?

Vincent Warmerdam: Calmcode, Explosion, Data Science | Learning From Machine Learning #2

Tue, 31 Jan 2023 14:31:25 GMT

Learning from Machine Learning, a podcast that explores more than just algorithms and data: Life lessons from the experts. This episode we welcome Vincent Warmerdam, creator of calmcode, and machine learning engineer at SpaCy to discuss Data Science, models and much more. @learningfrommachinelearning

Resources to learn more about Vincent Warmerdam:

https://calmcode.io/

https://youtu.be/kYMfE9u-lMo

https://youtu.be/S7vhi6RjBZA

https://github.com/koaning

References from the Episode:

You Look Like a Thing and I Love You: How Artificial Intelligence Works and Why It's Making the World a Weirder Place https://amzn.to/3Jt1qjX

The Future of Operational Research is Past https://ackoffcenter.blogs.com/files/the-future-of-operational-research-is-past.pdf

Supervised Learning is great - it's data collection that's broken https://explosion.ai/blog/supervised-learning-data-collection

Deon - An ethics checklist for data scientists https://deon.drivendata.org/

Hadley Wickham - https://hadley.nz/

Katharine Jarmul - https://www.linkedin.com/in/katharinejarmul/?originalSubdomain=de

Vicki Boykis - https://vickiboykis.com/

Brett Victor - https://youtu.be/8pTEmbeENF4

Resources to learn more about Learning from Machine Learning:

https://www.linkedin.com/company/learning-from-machine-learning/

https://www.linkedin.com/in/sethplevine/

https://medium.com/@levine.seth.p

Maarten Grootendorst: BERTopic, Data Science, Psychology | Learning from Machine Learning #1

Mon, 09 Jan 2023 18:25:52 GMT

The inaugural episode of Learning from Machine Learning, a podcast that explores more than just algorithms and data: Life lessons from the experts.

This episode we welcome Maarten Grootendorst to discuss BERTopic, Data Science, Psychology and the future of Machine Learning and Natural Language Processing.

Towards Data Science Article featuring this interview

Resources to learn more about Maarten Grootendorst:

https://www.maartengrootendorst.com/

https://maartengr.github.io/BERTopic/

https://www.linkedin.com/in/mgrootendorst/

https://twitter.com/MaartenGr

https://medium.com/@maartengrootendorst

Resources to learn more about Learning from Machine Learning:

https://www.linkedin.com/company/learning-from-machine-learning/

https://www.linkedin.com/in/sethplevine/

https://medium.com/@levine.seth.p